Medias

Elevant’s best-selling biohacking product provides rapid NAD+ support, but its fast absorption enhances its effectiveness.

The Role of NAD+ in Cellular Health

Nicotinamide adenine dinucleotide (NAD+) is fundamental to cellular energy production, DNA repair, and overall metabolic health. However, levels decline with age, contributing to reduced mitochondrial function, cognitive impairment, and a higher risk of age-related diseases. Research indicates that supplementing with nicotinamide mononucleotide (NMN), a precursor to NAD+, may help counteract this decline, enhancing energy levels, cognitive function, and overall cellular resilience [1], [2], [3].

Optima’s Unique Approach to NMN Supplementation

Elevant’s Optima, which contains 250 mg of NMN-C per dose, has been formulated to support NAD+ restoration with a notable distinction – its chewable format allows for direct absorption via the salivary glands. This approach bypasses the digestive system’s potential inefficiencies, facilitating rapid entry into the bloodstream and enhancing its bioavailability. The product’s efficacy has drawn attention from longevity researchers and practitioners, including Peter Diamandis, who highlighted Optima in his recent Longevity Guidebook.

The Importance of Bioavailability in NMN Supplementation

While NMN has been extensively studied for its ability to support NAD+ levels, absorption remains a key consideration. Standard oral NMN supplements must pass through the gastrointestinal tract, where breakdown and conversion processes can limit efficiency. However, Optima’s sublingual absorption allows NMN to reach systemic circulation more quickly, making it particularly relevant for individuals seeking an immediate effect on cognitive function and metabolic processes.

Clinical and preclinical studies on NMN support its role in aging and metabolic health. Research suggests NMN supplementation can improve endurance, mitigate inflammation, and enhance mitochondrial function. A human trial demonstrated NMN’s ability to improve exercise performance in runners [4], while other studies indicate its potential to support brain health and inflammatory responses comparable to conventional anti-inflammatory agents [5], [6].

Nutritional Balance as a Prerequisite for NAD+ Optimization

Despite NMN’s potential, optimal absorption and efficacy rely on adequate vitamin and mineral levels. NAD+ metabolism is influenced by cofactors such as magnesium, zinc, and B vitamins, which support enzymatic processes involved in NAD+ synthesis and use. Deficiencies in these nutrients can impair NAD+ production, diminishing the benefits of supplementation.

Recognizing this, Elevant has expanded its product range to include formulations designed to maintain essential nutritional balance. By ensuring that key vitamins and minerals are present at optimal levels, these supplements complement NMN intake, facilitating more effective NAD+ replenishment and broader metabolic support.

Elevant’s Clinical Approach to Longevity Support

Elevant’s NMN-C® is produced to pharmaceutical-grade standards and is backed by extensive in-human clinical research. The company has focused on developing rigorously tested formulations, aligning with the broader scientific consensus on NAD+ supplementation’s potential benefits. Optima’s growing popularity, bolstered by endorsements from longevity experts, reflects increasing recognition of NMN’s role in promoting healthspan and mitigating age-related decline.

Insights from Longevity Research

Elevant partnered for its R&D with the renowned Buck Institute for Research on Aging to create and test NMN-C. When we spoke to Dr. Eric Verdin, President of The Buck Institute, about NMN supplementation, he explained that understanding the underlying biology was key.

“We know in humans and in animal models, NAD+ levels decrease with aging, but they might be decreasing at different rates in different people,” he explained. “And there might be different rates of decrease in different tissues and organs – this is hard to measure in people!

“Everyone above 50 should consider taking NMN and would potentially benefit from it. There is so much excitement in the field because the data is compelling – it really has a protective effect. My recommendation would be to buy it and take it at the recommended dosage and wait for the science to emerge. I take it!”

The Future of NMN Supplementation

As research on NAD+ and NMN progresses, the emphasis remains on maximizing absorption and ensuring supplementation occurs in a biologically supportive context. By combining fast-acting delivery with nutritional balance, Elevant’s Optima presents a scientifically considered approach to biohacking and longevity-focused health support.

Photographs courtesy of Elevant

The full article is available here: Optima: The Fast-Absorbing NMN Supplement Gaining Attention.